The Monacan Indian Nation is one of eleven Native American tribes recognized since the late 20th century by the U.S. state of Virginia. In January 2018, the United States Congress passed an act to provide federal recognition as tribes to the Monacan and five other tribes in Virginia. They had earlier been so disrupted by land loss, warfare, intermarriage, and discrimination that the main society believed they no longer were "Indians". However, the Monacan reorganized and asserted their culture.

In the 21st century, the Monacan nation is located primarily in their traditional territory of Virginia's Piedmont region, particularly in Amherst County near Lynchburg. As of 2018 the Monacan Indian Nation has approximately 2,000 members. There are satellite groups in West Virginia, Maryland, Tennessee, and Ohio.

The Monacan nation was first recorded by Jamestown settlers in colonial Virginia. Their native language is a Siouan language which is extinct. The people are related to other Siouan-speaking tribes of the inland in this region, such as the Tutelo, Saponi and Occaneechi.